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针对宫癌患者量身定制的监测策略的年度复发风险模型的外部验证
Luigi A De Vitis1, Gabriella Schivardi2, Aurora Gaeta3
1Mayo Clinic, Department of Obstetrics and Gynecology, NY, USA; IRCCS, European Institute of Oncology, Department of Gynecologic Oncology, Milan, Italy.
概括
年度复发风险模型 (ARRM) 通过复发风险有效地分层宫癌患者. 这项验证证实了其在预测无病生存率和指导后续策略方面的有用性.
科学领域:
- 在瘤学瘤学.
- 妇科瘤学 妇科瘤学
- 癌症流行病学 癌症流行病学
背景情况:
- 年度复发风险模型 (ARRM) 是一种工具,旨在预测宫癌复发的年度风险.
- 该ARRM是由宫癌监测联盟开发的,并得到了欧洲妇科瘤学会的认可.
- 需要对ARRM进行外部验证,以确认其在不同患者群体中的预测准确性.
研究的目的:
- 在宫癌患者队列中对年度复发风险模型 (ARRM) 进行外部验证.
- 评估ARRM根据其复发可能性将患者分为不同的风险组的能力.
- 评估ARRM分配的风险组与5年无病生存率之间的相关性.
主要方法:
- 一项回顾性研究包括411名病理确诊的T1a至T2b宫癌患者,这些患者接受了激进手术治疗.
- 用ARRM风险计算器将患者分为五个风险组 (0,1-25,26-50,51-75,76-100分) 使用ARRM风险计算器.
- 使用日志级测试分析了无疾病生存率,并通过条件生存分析确定了每年复发风险.
主要成果:
- 该研究包括411名患者,其中大多数患者属于1-25 (36.3%) 和26-50 (54.5%) 点风险组.
- 风险组之间观察到无病5年生存率的显著差异 (p < .01),分别为1-25,26-50和51-75点组的96.3%,85.7%和66.6%.
- 在最低风险组 (1-25分) 中,从第1年到第5年每年复发风险约为1%.
结论:
- 该ARRM在将子宫癌患者分为具有明显不同无病生存结果的群体中证明了有效性.
- 这些发现支持ARRM作为预测子宫癌复发风险在独立患者队列中的工具的实用性.
- 考虑到每年复发的风险,以及患者的观点,对于定制有效的后续护理至关重要.
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