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肠道IL-25通过调节肠道上皮细胞中的胆固醇载体NPC1L1表达来预防高脂肪饮食引起的肥胖

Siranart Jeerawattanawart^1,2, Pornpimon Angkasekwinai^3,4

¹Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, 12120, Thailand.

Scientific reports

|March 27, 2025

概括

肠道干白素-25 (IL-25) 在肥胖症下降,并可能调节新陈代谢. 在肠道中增加IL-25可降低肥胖标志物和胆固醇吸收.

科学领域:

代谢研究的研究.
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

肠道在消化和营养吸收中起着关键作用.
肥胖和肠道炎症与代谢功能障碍有关.
介质素-25 (IL-25) 是来自上皮细胞的细胞因子,与代谢障碍有关.

研究的目的:

为了研究肠道IL-25在高脂肪饮食 (HFD) 诱导的肥胖中的作用.
了解IL-25如何影响肥胖期间的代谢参数和肠道功能.

主要方法:

在HFD的小鼠中评估IL-25表达.
使用过基因小鼠过度表达肠道IL-25.
使用人类肠道Caco-2细胞进行了体外研究.

主要成果:

HFD降低了肠道IL-25表达,与代谢标记物相反相关.
在HFD小鼠中,肠道IL-25的过度表达减少了肥胖,降低了血脂和葡萄糖,减少了脂肪积累.
IL-25抑制了Caco-2细胞中的胆固醇吸收和NPC1L1表达.

结论:

肠道IL-25作为肠道胆固醇吸收的调节剂.
IL-25调节系统代谢和肥胖.
IL-25是肥胖和相关代谢功能障碍的潜在治疗标.

关键词:

胆固醇的吸收胆固醇的吸收它们是IL-25和IL-25.肠道肠道肠道 NPC1L1L1 的使用情况肥胖问题肥胖问题

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