癌症患者中Covid-19死亡的差异和这种关系的可能调解者
Leah Vaidya1, Nubaira Rizvi1, Xiao-Cheng Wu2
1Biostatistics and Data Science, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Scientific reports
|March 27, 2025
概括
非西班牙裔黑人癌症患者的COVID-19死亡率高出6.46倍. 伴随性疾病,特别是脏疾病,解释了这种差异的12.7%,突显了针对性干预的必要性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 与非西班牙裔白人相比,非西班牙裔黑人人口的COVID-19死亡率更高.
- 癌症是致命的COVID-19结果的一个公认的风险因素.
- 现有的研究已经探讨了COVID-19住院患者的并发症,但没有探讨COVID-19相关死亡.
研究的目的:
- 调查查尔森并发症指数 (CCI) 和个别疾病是否解释非西班牙裔黑人和非西班牙裔白人癌症患者在COVID-19死亡率中的差异.
- 确定导致非西班牙裔黑人癌症患者COVID-19死亡率过高的特定并发症.
主要方法:
- 对非西班牙裔黑人和非西班牙裔白人癌症患者 (年龄≥20) 的分析,这些患者在2011-2019年期间被诊断出患有COVID-19的,他们通过2021年6月30日的COVID-19检测结果呈阳性.
- 利用了路易斯安那州瘤登记处的数据.
- 进行了两个调解分析:首先,评估整体并发症 (CCI),其次,评估个人并发症对COVID-19死亡率差异的贡献.
主要成果:
- 非西班牙裔黑人癌症患者的COVID-19死亡风险比非西班牙裔白人患者高6.46倍.
- 查尔森并发症指数 (CCI) 占COVID-19死亡率观察到的差异的12.7%.
- 病是最重要的个人并发症,解释了4.9%的死亡率差异.
结论:
- 伴随性疾病,特别是脏疾病,在解释非西班牙裔黑人癌症患者中COVID-19死亡率升高方面发挥着重要作用.
- 研究结果表明,管理诸如脏病等慢性疾病可能对制定有针对性的干预措施来减少COVID-19死亡率差异至关重要.
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