Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Contact-dependent Signaling01:19

Contact-dependent Signaling

44.3K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
44.3K
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

2.8K
The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections...
2.8K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.5K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.5K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.3K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.3K
Cell-surface Signaling01:21

Cell-surface Signaling

51.4K
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
51.4K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

6.5K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
6.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells.

Nature chemistry·2026
Same author

Tumor immune cell targeting chimeras reprogram tumor-associated macrophages.

Nature chemical biology·2026
Same author

Iterative Bump-and-Hole Engineering Creates a Bioorthogonal Reporter for <i>N</i>-Acetylglucosaminyltransferase I.

Journal of the American Chemical Society·2026
Same author

Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling.

bioRxiv : the preprint server for biology·2026
Same author

Ageing promotes microglial accumulation of slow-degrading synaptic proteins.

Nature·2026
Same author

Improved protein binder design using β-pairing targeted RFdiffusion.

Nature communications·2026

相关实验视频

Updated: May 20, 2025

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
00:08

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells

Published on: September 2, 2019

7.0K

在细胞表面的诱导性接近.

Nicholas A Till1,2, Muthukumar Ramanathan2,3, Carolyn R Bertozzi4,5,6

  • 1Department of Chemistry, Stanford University, Stanford, CA, USA.

Nature biotechnology
|March 27, 2025
PubMed
概括
此摘要是机器生成的。

诱导近距离工程使用双功能分子控制细胞表面蛋白质. 这种方法具有治疗潜力,并有助于理解针对蛋白质降解和信号调节的生物机制.

更多相关视频

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
13:10

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

Published on: June 9, 2017

9.9K
A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts
08:43

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

Published on: December 1, 2018

11.3K

相关实验视频

Last Updated: May 20, 2025

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
00:08

In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells

Published on: September 2, 2019

7.0K
Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
13:10

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

Published on: June 9, 2017

9.9K
A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts
08:43

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

Published on: December 1, 2018

11.3K

科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 化学生物学 化学生物学

背景情况:

  • 分子接近对于细胞功能至关重要,包括受体调节和蛋白质循环.
  • 细胞表面的蛋白质与蛋白质相互作用控制着关键的生物通路.
  • 不调节的近距离有助于各种疾病状态.

研究的目的:

  • 审查诱导近距离在调节细胞表面蛋白中的应用.
  • 突出治疗潜力和在生物研究中使用诱导的近距离.
  • 探索细胞生物学中基于近距离的策略的未来.

主要方法:

  • 该综述综合了当前关于诱导近距离策略的研究.
  • 专注于旨在控制蛋白相互作用的双功能分子.
  • 检查了针对蛋白质降解,受体抑制和信号激活的应用.

主要成果:

  • 诱导的近距离可以精确控制细胞表面蛋白活性.
  • 在向蛋白质降解和受体调节方面表现出有用性.
  • 通过工程近距离促进细胞内信号级联的激活.

结论:

  • 诱导近距离是基础研究和治疗开发的强大工具.
  • 为调节细胞表面蛋白质功能提供了多功能策略.
  • 对于未来分子工程和医学方面的进步具有重大前景.