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相关实验视频

Updated: May 20, 2025

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

整合了可伸缩纳米电子的赛博格器官可以在开发过程中功能地图.

Zuwan Lin^1,2, Wenbo Wang^1,2, Ren Liu¹

¹John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.

Nature protocols

|March 27, 2025

概括

赛博格器官技术将灵活的纳米电子与3D器官相结合,用于长期,单细胞监测器官发育和功能. 这一突破使详细的组织范围的功能映射成为可能,进步了有机体研究和应用.

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科学领域:

生物技术是生物技术.
生物工程是生物工程.
材料科学材料科学材料科学

背景情况:

机器人是一种先进的体外模型,用于研究器官发育,疾病和药物反应.
目前的监测方法缺乏全面的3D有机体分析的分辨率和持续时间.
在单细胞分辨率下持续的长期监测对于理解复杂的有机体动态至关重要.

研究的目的:

开发一种用于持续,长期,单细胞分辨率监测有机体活动的新技术.
为了整合可伸缩网状纳米电子在3D器官中进行功能映射.
克服现有技术在记录时间,空间覆盖和组织接触方面的局限性.

主要方法:

可伸缩网状纳米电子产品的制造和表征,具有类似组织的特性.
纳米电子产品在有机生成过程中通过2D到3D重构过程集成到3D有机体中.
使用多模式数据分析获得长期功能性有机体活性.

主要成果:

证明纳米电子在有机体中无集成,保持组织特性.
启用了有机体的纵向,全组织,单细胞功能映射.
克服了记录时间,空间覆盖和稳定的组织接触方面的限制.

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Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

相关实验视频

Last Updated: May 20, 2025

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

结论:

赛博基有机体技术为有机体研究和开发提供了一个变革性的工具.
这项技术增强了体外疾病建模,药物查和个性化医疗.
该协议要求在干细胞生物学,组织工程,纳米电子学,电生理学和数据科学方面拥有多学科的专业知识.