阴道宿主免疫-微生物组-代谢物相互作用与白人占主导地位的队列中的自发早产有关
Megan Cavanagh1, Emmanuel Amabebe1, Neha S Kulkarni1
1Division of Clinical Medicine, University of Sheffield, Sheffield, UK.
NPJ biofilms and microbiomes
|March 27, 2025
概括
预测自发早产 (sPTB) 风险包括分析阴道微生物群和代谢物. 通过这些标记物的早期检测可以改善孕妇的风险分层.
科学领域:
- 产科和妇科 产科和妇科
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 自发早产 (sPTB) 仍然是新生儿发病率和死亡率的主要原因.
- 目前的风险分层方法存在局限性,特别是在不同人群中.
- 了解宫和阴道环境的动态相互作用对于改善预测至关重要.
研究的目的:
- 增强非分娩孕妇的自发早产 (sPTB) 风险分层.
- 调查与sPTB相关的阴道微生物群,代谢物和细胞因子的纵向变化.
- 确定生物标志物,以改善sPTB风险评估.
主要方法:
- 在两个妊娠时间点 (GTP1: 20-22周;GTP2: 26-28周) 分析阴道微生物群,代谢物和细胞因子度.
- 在早产和到期分娩的妇女之间比较生物标志物.
- 评估与其他标记物结合的胎儿纤维生素 (FFN).
主要成果:
- 在GTP1中,增加的G. vaginalis丰度与早产有关.
- 在GTP2中,早产的女性表现出明显的微生物群 (乳酸菌/混合无气体),高调代谢物和TNFR1降低,相比于早产的女性.
- 纵向分析显示,在sPTB病例中,微生物群的α-多样性增加,以及从GTP1到GTP2的泛氨酸和尿酸的上调调. 在sPTB病例中,CXCL10增加,并且被FFN增强.
结论:
- 宫内微生物群,代谢物和免疫标记物 (如CXCL10) 的动态变化与自发早产风险有关.
- 整合这些动态相互作用可以显著改善sPTB风险分层.
- 对这些复杂的相互作用进行进一步的研究有必要进行临床应用.
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