人类测量措施与发生事件风险之间的关系 代谢功能障碍相关的脂肪性肝病:一项纵向研究
Takahiro Ichikawa1, Yoshitaka Hashimoto1,2, Takuro Okamura1
1Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
BMC gastroenterology
|March 27, 2025
概括
体重指数 (BMI) 和腰围 (WC) 有效地预测新发代谢功能障碍相关的脂肪性肝病 (MASLD),特别是在男性中. 对于亚洲人群中最佳的WC标准,需要进一步的研究.
科学领域:
- 代谢健康和肝脏疾病研究.
- 人类测量测量和疾病预测.
- 公共卫生和预防医学.
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 诊断通常依赖腰围 (WC) 和体重指数 (BMI).
- 像身体圆度指数 (BRI) 和腹部体积指数 (ABSI) 这样的替代人体指数可以提供对MASLD风险的见解.
- 研究新型标志物对于改善MASLD的早期检测和管理至关重要.
研究的目的:
- 为了比较BRI和ABSI与传统WC和BMI的事件MASLD的预测能力.
- 评估不同的人类测量指标与日本队列中MASLD的发展之间的关联.
- 确定BMI和WC的最佳切断值,以预测按性别分层的MASLD.
主要方法:
- 来自日本健康检查计划的回顾性数据的分析.
- 后勤回归模型用于评估人体测量和MASLD之间的关联.
- 接收器操作特征 (ROC) 曲线分析,以评估事件 MASLD 的预测准确性.
主要成果:
- 较高的WC,BMI和BRI与男性和女性发生MASLD的风险增加有关.
- 只有在女性中,ABSI与发生的MASLD有显著的关联.
- BMI在男性和女性中显示了MASLD的最高预测准确度 (曲线下的面积),其次是女性的WC和BRI.
结论:
- 体重指数 (BMI) 显示出与发生的MASLD最强的关联,特别是在男性中.
- 腰围 (WC) 也起着重要作用,但改善MASLD诊断可能需要针对亚洲人群的具体标准.
- 当前的人类测量措施,特别是BMI,是预测MASLD发病率的宝贵工具.
相关概念视频
Overview of Lipid Metabolism
885
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
885
Obesity
353
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
353


