益生菌对早产婴儿死性肠球炎的影响:随机对照试验的网络元分析
Yu Dai1, Qinlei Yu1, Fan Zhang1
1Department of Pediatrics, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, 123 Tian Fei Xiang, Mo Chou Road, Nanjing, 210004, China.
BMC pediatrics
|March 27, 2025
概括
益生菌显著降低死性肠球炎 (NEC) 和早产婴儿的死亡率. 特定的组合,比如Bifidobacterium,Lactobacillus和Enterococcus,显示出最有希望的改善结果和更短的住院时间.
科学领域:
- 新生儿医学 新生儿医学
- 微生物组研究 微生物组研究
- 临床营养学 临床营养学
背景情况:
- 以前的研究表明,益生菌对早产婴儿有好处,但疗效因菌株而异.
- 结核性肠球炎 (NEC) 仍然是早产婴儿护理的一个重要问题.
- 对早产婴儿的最佳益生菌策略需要进一步研究.
研究的目的:
- 评估各种益生菌在预防早产婴儿中NEC和相关结果方面的有效性.
- 进行一个网络元分析,比较不同的益生菌干预与安慰剂.
- 为了确定具有最大临床益处的特定益生菌物种或组合.
主要方法:
- 51个随机对照试验的网络元分析.
- 包括11,661名早产婴儿在内.
- 评估结果,包括NEC发病率,死亡率,住院时间和进食时间.
主要成果:
- 大多数益生菌降低了NEC发病率 (贝尔的II阶段或更高).
- 特定组合 (Bifidobacterium,Lactobacillus,Streptococcus) 显著降低了所有原因的死亡率.
- 单独的乳酸菌可以缩短住院时间,并加速全肠道养.
结论:
- 结合Bifidobacterium,Lactobacillus和Enterococcus,在减少NEC和死亡率方面表现出最高的疗效.
- 益生菌和乳酸菌单一治疗有效地减少了住院时间和完全肠道养的时间.
- 在本次分析中,益生菌对败血症风险没有显著影响.
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