相关实验视频
Updated: May 20, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
该miR-876-5p/SOCS4/STAT3通路诱导PD-L1的表达,并抑制了抗瘤免疫反应
Hsuan-Yu Peng1,2,3, Yu-Li Huang4, Ping-Hsiu Wu5,6,7,8
1School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
微RNA miR-876-5p通过增强细胞生长和免疫逃避,促进口腔癌复发. 针对这种微RNA及其通路可以改善口腔状细胞癌患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 口腔状细胞癌 (OSCC) 具有重大挑战,复发率高,预后不佳.
- 确定OSCC复发的分子驱动因素对于改善患者的治疗结果至关重要.
研究的目的:
- 研究微RNAmiR-876在OSCC复发和进展中的作用.
- 阐明miR-876在OSCC中的功能背后的分子机制.
主要方法:
- 在复发性OSCC组织中分析miRNA表达特征.
- 在体外功能测定 (细胞生长,迁移,干性,化学抵抗).
- 涉及基因向 (SOCS4,STAT3,PD-L1) 和致癌物暴露 (NNK) 的机制研究.
主要成果:
- 在复发的OSCC中,miR-876-5p显著上调,并且与生存率降低相关.
- miR-876-5p促进了OSCC细胞的生长,迁移,干细胞和化学抵抗.
- miR-876-5p针对SOCS4,增加STAT3激活和PD-L1表达,导致免疫逃逸.
- 暴露于NNK诱导了miR-876的表达和STAT3的激活.
结论:
- 在OSCC的进展和复发中,miR-876-5p-SOCS4-STAT3轴是关键途径.
- miR-876-5p是预测OSCC复发的潜在生物标志物.
- miR-876-5p是改善OSCC治疗结果的有希望的治疗标.
更多相关视频
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
相关概念视频
Abnormal Proliferation
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
The JAK-STAT Signaling Pathway
The Intrinsic Apoptotic Pathway
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway