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心血管异常已经发生在新诊断的2型糖尿病早期发病的患者中
Hong Lian1, Qian Ren1, Wei Liu1
1Department of Endocrinology, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
心血管异常常见于新诊断的早期发病的2型糖尿病 (EOD). 肥胖和胰岛素耐药性增加了这些早期心脏和动脉问题的风险,有助于早期识别患者.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 在全球范围内,早期发病的2型糖尿病 (EOD) 的患病率正在上升.
- 心血管并发症是EOD患者的一个主要问题.
- 早期发现心血管异常对于风险分层至关重要.
研究的目的:
- 在新诊断的EOD患者中选早期心血管异常.
- 评估不同患者群体表型的心血管风险.
- 确定与EOD中心血管并发症相关的关键临床因素.
主要方法:
- 分析了400名40岁以下的新发型2型糖尿病患者.
- K-意味着用于表型分类的临床和生化数据的聚类.
- 心声图和带超声波评估了心脏和血管健康.
- 分区多基因分数 (pPS) 用于遗传验证.
主要成果:
- 26.3%的人有动脉异常;20.0%的人有心声异常.
- 严重的胰岛素抵抗性糖尿病 (SIRD) 显示出最高的动脉异常率 (40.0%).
- 更高的BMI,C-和HOMA2IR与增加左心房扩大风险相关.
结论:
- 心血管和动脉异常在EOD的诊断时很普遍.
- 肥胖和胰岛素抵抗是EOD中心血管并发症的关键风险因素.
- 基于表型的集群改进了早期识别高风险的EOD患者.
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