探索亚临床甲状腺功能低下症和严重抑郁症对大脑网络的相互作用影响
Shuai Zhao1,2,3,4,5, Jindan Wu6, Xiaomei Liu6
1Department of Psychiatry, The Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
BMC medicine
|March 27, 2025
概括
重度抑郁症 (MDD) 与亚临床甲状腺功能低下症 (SHypo) 显示大脑连接性发生变化,特别是在视觉和感觉运动网络中. 这些变化可能表明,在患有并发性SHypo和MDD的患者中,认知功能存在补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 大型抑郁症 (MDD) 经常与身体疾病同时发生.
- 亚临床甲状腺功能低下症 (SHypo) 是MDD患者常见的并发症.
- 这种并发症可能会导致大脑结构和功能发生显著变化.
研究的目的:
- 调查MDD和SHypo.的同时发生的基础的神经机制.
- 用数据驱动方法分析大脑活动模式.
- 为了确定与MDD的共病性SHypo相关的静止状态功能连接 (FC) 的变化.
主要方法:
- 招募的参与者:没有SHypo的MDD (nSHypo-MDD),有SHypo的MDD (SHypo-MDD),只有SHypo,以及健康的对照 (HC).
- 用于所有参与者的静止状态功能磁共振成像 (fMRI) 扫描.
- 进行了全面的神经心理评估.
主要成果:
- 在腹部和背部感觉运动网络 (VSMN和DSMN) 和极视觉网络 (PVN) 中观察到显著改变的FC.
- 与nSHypo-MDD患者相比,SHypo-MDD患者在左骨 (PVN) 中表现出较高的FC.
- FT3水平与补充运动区域 (SMA.R) 的FC相反相关,左皮FC与认知测试分数 (DSST) 呈正相关.
结论:
- 该研究在SHypo-MDD患者中发现了显著的FC变化,特别是在PVN,VSMN和DSMN内.
- 这些变化表明了潜在的补偿机制,旨在减轻认知缺陷.
- 综合管理SHypo和MDD对于改善受影响个体的认知结果至关重要.
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