在多种 {PEG 400 + 水} 组合中,利博基利布的温度依赖溶解和热力学特性
Faiyaz Shakeel1, Ramadan Al-Shdefat2, Mohammad Ali3
1Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
BMC chemistry
|March 27, 2025
概括
抗癌药物 рибоцилиб (RCB) 在聚乙烯糖醇 400 (PEG 400) 和水混合物中溶解度增加. 这项研究强调了PEG 400.
科学领域:
- 物理化学 物理化学
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 利博西克利布 (RCB) 是一种重要的抗癌药物.
- 了解其溶解度对于有效的药物配方至关重要.
- 聚乙烯甘醇400 (PEG 400) 是一种常见的制药溶剂.
研究的目的:
- 为了确定 ribociclib (RCB) 的可溶性和热力学特性.
- 为了研究RCB在各种聚乙烯糖醇400 (PEG 400) +水混合物中的溶解性.
- 评估不同热力学模型对于预测RCB溶解度的适用性.
主要方法:
- 使用和振动瓶法实验性确定RCB溶解度.
- 用多个热力学模型验证实验数据 (范特霍夫,阿佩尔布拉特,乔伊班-阿克里等). ) 的情况.
- 热力学参数估计以了解溶解行为.
主要成果:
- 随着PEG 400质量分数和温度的提高,RCB溶解度显著增加.
- 在纯PEG 400中观察到的最大RCB溶解度,而最小溶解度是在纯水中.
- 溶解过程是内热和驱动的,在PEG 400中具有更强的分子相互作用.
结论:
- 聚乙烯甘醇400 (PEG 400) 显示出在水系统中溶解里博基 (RCB) 的极佳潜力.
- 热力学模型准确地预测实验RCB可溶性数据.
- 这些发现支持PEG 400在制造基于里博基的药物中的使用.
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