在自闭症中功能连接体层次的非典型成熟
Jong-Eun Lee1,2, Sunghun Kim1,2, Shinwon Park3
1Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Molecular autism
|March 27, 2025
概括
自闭症谱系障碍 (ASD) 显示出异常的大脑发育,儿童期成熟延迟,网络功能发生改变. 针对高阶网络的早期干预对于改善ASD患者的治疗结果至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 脑部成像 脑部成像
背景情况:
- 自闭症谱系障碍 (ASD) 涉及到感官处理和社会认知功能的干扰,表明复杂的大脑网络相互作用.
- 在ASD中皮层层次的发育轨迹尚不清楚,需要对成熟异常进行调查.
研究的目的:
- 调查患有自闭症谱系障碍 (ASD) 个体皮层层次中的成熟异常.
- 描述ASD患者一生中功能性大脑组织的发展轨迹.
主要方法:
- 分析了来自三个大型数据集的休息状态功能磁共振成像 (fMRI) 数据 (自闭症脑成像数据交换I和II,寿命人类连接组项目开发).
- 使用扩散地图嵌入来估计皮层层次,规范建模 (GAMLSS) 捕获了ASD的非线性发展轨迹和个体偏差.
- 调解分析检查了网络连接组中断在非典型皮质层次结构发展中的作用.
主要成果:
- 患有自闭症的个体表现出皮层层次的非线性成熟,儿童发育延迟,青少年追赶速度加快,随后在年轻成年期出现下降.
- 感官和注意网络在童年时表现出明显的异常,而高阶网络,包括默认模式网络 (DMN),从童年到青春期仍然受到损害.
- 在整个发育过程中减少的DMN分离被确定为ASD非典型皮质层次发展的关键贡献者.
结论:
- 了解皮层组织的发展轨迹对于ASD研究至关重要.
- 研究结果表明,针对高阶网络规范性发展的早期干预措施可能会改善ASD患者的结果.
- 限制包括不同年龄组的样本分布不均,特别是在后期的发育阶段.
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