乳球球菌 (Lactococcus cremoris) PS133对5-基三胺诱导的刺激性肠综合征模型大鼠的影响
Fu-Sheng Deng1, Miao-Hui Lin2, Chin-Lin Huang1,3
1Bened Biomedical Co., Ltd., Taipei 115011, Taiwan.
International journal of molecular sciences
|March 27, 2025
概括
乳球球菌克雷莫里斯PS133通过改善肠道屏障完整性和调节肠道微生物群,减少了大鼠的易怒肠综合征 (IBS) 症状. 这种益生菌显示了通过增强肠道健康来管理IBS的前景.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 刺激性肠综合征 (IBS) 是一种功能性胃肠疾病,其特点是腹痛和改变肠道习惯.
- 肠道微生物群失生症越来越多地被认为是IBS病变的促成因素.
- 益生菌为恢复肠道健康和缓解IBS症状提供了潜在的治疗策略.
研究的目的:
- 为了研究乳球球菌PS133 (PS133) 对由5-基酸 (5-HTP) 诱导的IBS大鼠模型的影响.
- 在IBS模型中评估PS133对内脏过敏,肠道屏障功能,神经递质水平和肠道微生物群组成的影响.
主要方法:
- 斯普拉格·道利大鼠接受了PS133或盐水的治疗,随后给予5-HTP以诱导IBS类症状.
- 用结直肠张张测试来评估内脏过敏性.
- 通过测量粘素降解和紧结蛋白表达 (occludin, zonula occludens-1) 来评估肠道屏障的完整性.
- 分析了神经递质水平 (物质P,5-氨酸) 和肠道微生物群组成.
主要成果:
- 在5-HTP诱导的IBS模型中,PS133显著降低了内脏过敏.
- PS133保护了肠道粘素免受降解,并增加了紧结蛋白水平,表明肠道屏障完整性得到了增强.
- PS133调节了脊髓和大脑中的神经递质水平,并调节了包括Eubacterium和Lactococcus在内的特定肠道细菌群.
结论:
- 乳球球菌克雷莫里斯PS133在小鼠模型中证明有效改善IBS类症状.
- PS133改善了肠道屏障功能,使神经递质水平正常化,并调节了肠道微生物群的组成.
- 这些发现支持PS133作为治疗性治疗剂的潜力,用于控制易怒肠综合征.
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