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甘酸通过通过肠道微生物群调节改善肠道屏障功能来改善性结肠炎.

Yuwei Ye1, Abudumijiti Abulizi1, Yukun Zhang1

  • 1State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.

International journal of molecular sciences
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PubMed
概括

来自Ganoderma lucidum的甘酸 (GA) 在治疗性结肠炎 (UC) 中表现有前途. GA改善了肠道屏障功能并改变了肠道微生物群,为UC患者提供了潜在的治疗策略.

关键词:
甘酸是一种甘酸.我们的肠道微生物群.肠道屏障的功能是肠道屏障的功能.紧密的交叉路口紧密的连接性结肠炎是一种

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科学领域:

  • 胃肠病学 胃肠病学
  • 药理学 药理学是指药理学的学科.
  • 微生物学 微生物学

背景情况:

  • 性结肠炎 (UC) 是一种慢性炎症性肠病,具有重大的全球健康和经济影响.
  • 目前对UC的治疗需要开发新的,安全和有效的治疗药物.

研究的目的:

  • 为了研究甘酸 (GA) 的预防和治疗潜力,甘酸是Ganoderma lucidum的关键成分,在硫酸 (DSS) 诱导的UC的小鼠模型中.

主要方法:

  • 将GA给DSS诱导的UC小鼠,以评估其对疾病活性,结肠长度和脏指数的影响.
  • 评估肠道炎症标记物和紧结蛋白表达 (ZO-1,奥克卢丁,克劳丁-1).
  • 共住和便微生物种移植实验以确定肠道微生物群的作用;16S rDNA测序以分析微生物组成;Caco-2细胞模型以评估与特定代谢物的屏障功能.

主要成果:

  • 在UC小鼠中,GA显著减轻了体重减轻和疾病活性指数.
  • GA治疗恢复了结肠长度和指数,减少了肠道炎症,并提高了紧结蛋白的调节,增强了肠道屏障功能.
  • 肠道微生物群被认为对GA的治疗作用至关重要,GA丰富了诸如Lactobacillus和Oscillospira之类的有益细菌,而特定的代谢物 (IAAld,Gln,GSH) 减少了屏障损伤.

结论:

  • 甘酸在临床前模型中对性结肠炎表现出显著的改善作用.
  • GA的治疗作用通过调节肠道微生物群和改善肠道屏障完整性来调节.
  • GA代表了UC的潜在治疗候选者,通过肠道微生物群和相关的代谢途径起作用.