新型生物活性树脂涂层与酸纳米颗粒具有抗菌和重矿化能力,可以对抗牙根
Nader Almutairi1,2,3, Abdullah Alhussein4, Mohammad Alenizy1,2,5
1Dental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD 21201, USA.
International journal of molecular sciences
|March 27, 2025
概括
一种新的树脂涂层通过释放和酸盐离子并抑制细菌来对抗牙根. 这种牙材料显示出有前途的机械性能,低细胞毒性和对Streptococcus mutans的有效性.
科学领域:
- 生物材料科学 生物材料科学
- 牙科研究 牙科研究
- 纳米技术纳米技术
背景情况:
- 牙根 кариес是一个重要的牙问题,占美国所有牙 кариес的10.1%.
- 现有的治疗方法缺乏多功能能力,无法解决根的复杂病因.
研究的目的:
- 开发和评估一种新型的多功能树脂涂层,用于预防和治疗牙根.
- 评估纳米尺寸无形酸盐 (NACP) 和二甲基胺甲基酸盐 (DMAHDM) 对涂层性能的影响.
主要方法:
- 一种含有尿二甲酸盐 (UDMA),三乙烯糖醇二乙烯乙烯 (TEGDVBE),DMAHDM和NACP的树脂涂层的合成.
- 评估机械性质 (柔性强度,弹性模量),物理性质,抗菌疗效对Streptococcus mutans,以及对牙髓干细胞和牙纤维细胞的细胞毒性.
- 与商业牙科密封剂进行比较:Seal&Protect和Vanish XT.
主要成果:
- 与Seal&Protect相比,实验树脂组表现出明显更高的屈曲强度,与Vanish XT相比,具有可比的强度.
- 该涂层表现出强烈的抗菌活性,实现了8log CFU的减少,并显著降低了代谢活动和乳酸生产.
- 在35天内观察到持续释放的 (Ca) 和 (P) 离子,对测试的细胞系具有低细胞毒性.
结论:
- 开发的多功能树脂涂层具有出色的抗菌性能,高离子释放能力和良好的机械完整性.
- 这种创新材料显示出预防和治疗牙根腐烂的巨大潜力.
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