慢性阻塞性肺病 (COPD) 中表观遗传变化的最新证据:系统性审查
Rosetta Ragusa1, Pasquale Bufano1,2, Alessandro Tognetti3
1Institute of Clinical Physiology, CNR, 56124 Pisa, Italy.
诸如DNA甲基化和非编码RNA等表观遗传因素是慢性阻塞性肺病 (COPD) 的关键. 这些修改为COPD患者提供了潜在的生物标志物和治疗点.
科学领域:
- 肺部医学和遗传学
- 专注于表观遗传学和呼吸系统疾病的交集.
背景情况:
- 慢性阻塞性肺病 (COPD) 是一种复杂的炎症性肺病,受遗传和环境因素的影响.
- 表观遗传机制,即调节基因表达而不改变DNA序列的表观遗传机制,越来越多地被认为是其在COPD病变发生过程中的作用.
- 了解这些表观遗传变化对于确定新的治疗策略和诊断生物标志物至关重要.
研究的目的:
- 系统地审查有关COPD表观遗传修饰的当前知识.
- 确定潜在的表观遗传生物标志物和COPD的治疗点.
主要方法:
- 按照PRISMA指南,对PubMed和Scopus数据库进行系统的文献搜索 (2024年5月).
- 包括对人类患者的COPD相关表观遗传修饰的研究,并进行质量评估.
- 已识别的表观遗传机制的分类:DNA甲基化,基因素修饰和非编码RNAs.
主要成果:
- 51篇文章符合5414篇最初出版物中的入选标准.
- 鉴定了DNA甲基化 (8项研究),基因组修饰 (1项研究) 和非编码RNA (42项研究).
- 表观遗传元素主要调节COPD中的亡和炎症途径.
结论:
- 表观遗传修饰,特别是非编码RNA,在COPD的发展和进展中起着至关重要的作用.
- 这些表观遗传因素代表了开发新生物标志物和COPD治疗干预措施的有希望的途径.
- 需要进一步的研究来充分阐明表观遗传在COPD中的作用,并验证它们的临床实用性.
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