在高度饮食下,上皮的作用和相关变化
Ling Zhang1, Zhenhua Xia1, Jicheng Fu2
1College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
International journal of molecular sciences
|March 27, 2025
概括
高度饮食 (HCD) 可以在反动物中引起亚急性乳液酸化 (SARA). 本综述详细介绍了在HCD下皮表皮的变化如何对SARA病变产生贡献.
科学领域:
- 食动物的营养
- 动物生理学 动物生理学
- 胃肠病学 胃肠病学
背景情况:
- 高度饮食 (HCD) 改善了反动物的产量,但存在亚急性反酸性疾病 (SARA) 的风险.
- 由快速发酵的碳水化合物引起的乳头酸化引起的SARA,减少干物摄入量 (DMI) 并引起炎症.
- 乳头上皮 (RE) 在吸收,运输和屏障功能中起着至关重要的作用,使其成为SARA病变发生的核心.
研究的目的:
- 在高度饮食 (HCD) 下,审查皮上皮的结构,功能和反应 (RE).
- 为了阐明亚急性乳头酸性病变 (SARA) 病原体的细胞和分子机制.
- 了解HCD对RE功能和完整性的影响.
主要方法:
- 关于HCD,SARA和皮上皮的研究的文献综述.
- 在饮食挑战下对RE细胞和分子变化的分析.
- 综合关于SARA病变的当前知识.
主要成果:
- 短期的HCD食最初会增强RE的扩散和输送活性.
- 长时间的HCD养会损害RE功能,并促进炎症.
- 来自HCD的乳酸和SCFA的积累降低了 rumen的pH值,导致SARA.
结论:
- 乳头上皮在HCD下经历了显著的适应性和有害性变化,导致SARA.
- 了解RE对HCD的反应对于管理SARA和减轻反动物生产的经济损失至关重要.
- 本综述全面分析了RE在细胞和分子水平上SARA病原发生中的作用.
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