治疗前列腺癌的治疗方法:从成像到使用UniCAR T细胞的治疗:用治疗性E5B9-Bombesin目标模块 (TMs) 治疗前列腺癌
Liliana R Loureiro1, Susan Pike2,3, Melinda Wuest2,3
1Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01328 Dresden, Germany.
International journal of molecular sciences
|March 27, 2025
概括
使用bombesin的新目标模块 (TM) 对前列腺癌免疫疗法具有前景. 这些TM可实现诊断成像和免疫治疗,有效向GRPR表达瘤,增强稳定性.
科学领域:
- 在瘤学瘤学.
- 放射化学 放射化学是指辐射化学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 目标模块 (TM) 是UniCAR T细胞疗法和免疫疗法的关键.
- 前列腺癌表达胃蛋白释放受体 (GRPR),是治疗和成像的目标.
研究的目的:
- 开发和评估基于bombesin (BBN2) 的TMs用于前列腺癌免疫疗法.
- 评估使用PET的诊断成像潜力和使用UniCAR T细胞的免疫治疗疗效.
主要方法:
- 合成的单体和二元BBN2TMs.
- 在实验室中评估了GRPR结合.
- 评估了UniCAR T细胞激活和癌细胞根除.
- 在异种移植模型中进行PET成像.
- 在体内分析了体内的代谢稳定性.
主要成果:
- BBN2 TMs 展示了特定的GRPR结合,并有效地激活了UniCAR T细胞.
- 单体和二元BBN2TM都在消除前列腺癌细胞方面表现出高效率.
- PET成像在体内证实了目标接触,只有脏清除.
- 在BBN2TM中,体内代谢稳定性显著提高.
结论:
- 单体和二元BBN2TM是前列腺癌的有前途的免疫疗法.
- 这些TM提供了诊断成像和向免疫治疗的双重功能.
- 增强BBN2TMs的代谢稳定性对于其临床潜力至关重要.
更多相关视频
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
3.3K
10:47Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
Published on: February 3, 2015
8.7K
相关概念视频
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Tumor Immunotherapy
450
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
450
