影响男性生育能力,个人倾向,预防和干预的生活方式和环境因素
1MARGen (Molecular Assisted Reproduction and Genetics) Clinic, Calle Gracia 36, 18002 Granada, Spain.
International journal of molecular sciences
|March 27, 2025
概括
现代生活方式和环境暴露对男性生育能力产生重大影响. 本综述详细介绍了男性生殖健康的致病因素,分子机制和预防策略.
科学领域:
- 生殖医学 生殖医学
- 环境健康 环境健康
- 男人的健康 男人的健康
背景情况:
- 现代生活方式越来越多地具有不健康的习惯,对男性生育能力产生负面影响.
- 污染和工作场所毒素等环境因素也对男性生殖系统构成风险.
- 个人易感性因遗传,表观遗传和健康因素而有所不同.
研究的目的:
- 对影响男性生育能力的生活方式和环境因素的当前知识进行批判性审查.
- 探索这些对男性生殖系统的影响背后的分子机制.
- 介绍男性生育异常的预防策略和治疗选择.
主要方法:
- 关于男性生育能力的致病和易感因素的文献综述.
- 对各种风险因素的分子作用机制的分析.
- 综合目前关于预防和治疗方式的数据.
主要成果:
- 不健康的习惯 (吸烟,饮食不良等) 和环境暴露与男性不孕症有关.
- 这些因素会影响多个分子通路,导致不同的个体结果.
- 易感性受到遗传,表观遗传和健康状况的影响.
结论:
- 生活方式和环境因素是男性不孕症的重要因素.
- 了解分子机制对于开发有针对性的干预措施至关重要.
- 预防和及时治疗对于保护男性生殖健康至关重要.
相关概念视频
Infertility in Males
225
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
225
Spermatogenesis
101.9K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
101.9K
Disorders of the Male Reproductive System
283
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
283
Infertility in Females
253
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
253
Sex-linked Disorders
99.2K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
99.2K
Lifestyle Factors and Health
30
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
30


