在COVID-19后的流行病中,肝脏疾病的后果
1Department of Life Science, Health and Health Professions, Link Campus University, 00165 Roma, Italy.
Life (Basel, Switzerland)
|March 27, 2025
概括
随着COVID-19的流行,可能会导致长期的肝损伤,包括恶化现有的肝病或引起新的肝病,如脂肪肝病. 本综述探讨了这些肝脏表现的机制和后果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- COVID-19与不良肝脏结果有关,特别是在患有肝脏疾病的患者中.
- 长期的COVID-19可以表现为肝脏问题,包括慢性肝脏疾病的恶化或新发性肝脏疾病.
- 该病毒利用存在于肝细胞中的ACE2和TMPRSS2受体,导致肝损伤.
研究的目的:
- 审查COVID-19相关肝脏和肝胆损伤的病理生理机制.
- 探索COVID-19对肝炎,纤维化,代谢相关脂肪肝疾病 (MASLD) 和代谢功能障碍相关脂肪肝炎 (MASH) 的影响.
- 分析COVID-19对肝脏健康的短期和长期后果.
主要方法:
- 在PubMed数据库上进行文献搜索.
- 专注于以英语出版的研究.
- 审查病理生理机制,临床影响和COVID-19在肝脏上的后果.
主要成果:
- 后COVID-19肝脏发现包括脂肪和死体炎症.
- 观察到炎症,细胞分解和胆固醇酶指数的变化.
- 增加肝胆道病理的风险,包括二次胆道胆管炎和MASLD恶化.
结论:
- COVID-19对肝脏健康构成显著的短期和长期风险.
- 了解这些肝脏表现对于管理COVID-19后患者至关重要.
- 需要进一步的研究,以充分阐明对肝脏疾病的长期影响,特别是MASLD和MASH.
相关概念视频
01:26Diseases of the Liver and Gallbladder
408
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
408
01:29Chronic Pancreatitis II: Collaborative Care
51
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
51
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:28Esophageal Varices-II: Clinical Features and Management
32
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
32
01:30Acute Pancreatitis II: Clinical Manifestations and Management
76
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
76
01:30Liver Physiology
400
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
400