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Updated: May 20, 2025

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结构性洞察力对2-Haloacetophenone的非变异性

Hunmin Jung1,2, Naveen Kumar Rayala2, Ritesh Pal2

  • 1The Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.

Molecules (Basel, Switzerland)
|March 27, 2025
PubMed
概括

像N7-acetophenone-dG这样的庞大的DNA adducts可以采用syn conformation,阻碍DNA聚合酶eta活动. 这种结构变化阻止了核酸的结合,解释了这些病变的非变异性.

关键词:
造成的DNA损伤是DNA损伤.这是一种基化.突变发生的突变发生.转化合成的转化合成

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