聚乙烯/β-环素含有复合物的表征和体外益生菌活性
Chuan-Chao Wu1,2, Long Qian1, Zhen Rong1
1College of Biology and Food Engineering, Anhui Polytechnic University, Wuhu 241000, China.
Molecules (Basel, Switzerland)
|March 27, 2025
概括
固醇 (PTS) 含有β-环氧化 (β-CD) 的综合体增强了溶解性,并表现出双重益生菌效应. 这些复合物促进有益的肠道细菌,抑制有害的细菌,改善肠道菌群的组成.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 固醇 (PTS) 提供健康益处,但其水溶性和生物可用性较差.
- 开发有效的传递系统对于最大限度地发挥PTS的治疗潜力至关重要.
研究的目的:
- 为了合成和描述Pterostilbene/β-cyclodextrin (PTS/β-CD) 纳入复合物.
- 评估PTS/β-CD复合物的增强溶解性,稳定性和益生菌/益生菌功能.
主要方法:
- 通过相位溶解法进行合成;使用FTIR,SEM,XRD,NMR和分子对接进行表征.
- 模拟胃肠道消化和体外便发酵试验.
- 分析短链脂肪酸的产生和肠道微生物群的组成.
主要成果:
- 成功形成PTS/β-CD纳入复合体,其比例为1:1,稳定常数为166.7M-1.1.
- β-CD表现出对消化的抵抗,使结肠分娩成为可能;PTS表现出逐渐释放.
- PTS/β-CD显著增加了有益的短链脂肪酸 (,黄油,乳酸) 并促进了Bifidobacterium和Lactobacillus的生长.
结论:
- PTS/β-CD包容复合物有效地提高了PTS的溶解性和生物可用性.
- 这些复合物表现出显著的益生菌和益生菌特性,调节肠道微生物群的组成.
- PTS/β-CD通过促进有益细菌和抑制肠道中致病细菌来证明其双重功能.
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