炎症标记在评估糖尿病多神经病变的严重程度方面是否重要?
Muhammed Fuad Uslu1, Mustafa Yılmaz2
1Department of Internal Medicine, Elazığ Fethi Sekin City Hospital, 23280 Elazig, Turkey.
Medicina (Kaunas, Lithuania)
|March 27, 2025
概括
炎症标志物和脂质指数与糖尿病多神经病 (DPN) 严重程度有关,在患有糖尿病 (DM) 和糖尿病前期的患者中. 这些简单的测试可以帮助评估DPN风险,提供一个简单,低成本的临床工具.
科学领域:
- 内分泌学和新陈代谢学
- 神经学 神经学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 糖尿病神经病变 (DNP) 是糖尿病 (DM) 的常见并发症,由复杂的致病途径引起.
- 评估DNP的严重程度和风险对于患者的管理和预防进一步的并发症至关重要.
研究的目的:
- 评估血液学,炎症学,动脉瘤学和甘油三糖 (TyG) 指数参数在预测DNP发展和严重性的临床实用性.
- 在非糖尿病 (非糖尿病),糖尿病前期 (糖尿病前期) 和糖尿病 (糖尿病) 患者组中分析这些参数.
主要方法:
- 对62名非DM,97名前DM和327名DM患者的实验室参数进行了回顾性分析.
- 评估炎症标志物,脂质概况和代谢指标,包括TyG指数.
主要成果:
- 在前期的DM患者中,DNP严重程度与年龄和葡萄糖正相关,与LDL负相关.
- 在DM患者中,DNP严重程度与年龄,中性粒细胞,甘油三,葡萄糖,HbA1c,中性粒细胞与淋巴细胞的比率 (NLR),葡萄糖与淋巴细胞的比率 (GLR),甘油三/HDL的比率 (TG/HDL) 和TyG指数呈正相关性. 它与血小板 (PLT),HDL和淋巴细胞与单细胞比率 (LMR) 有负相关性.
- 在前-DM和DM患者组合中,年龄,GLR和TG/HDL与DNP严重程度呈正相关性,而甘油三和葡萄糖比率 (TGR) 呈负相关性.
结论:
- 炎症标志物和脂质指数在非DM,前DM和DM人群中确定DNP严重程度方面发挥着重要作用.
- 这些易于获得的参数为评估糖尿病多神经病症风险提供了一种新,可访问和具有成本效益的方法.
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