胆囊癌中的神经瘤综合征:一个系统性审查
Beth Shin Rei Lau1, Nevin Yi Meng Chua1, Wee Teck Ong1
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
Medicina (Kaunas, Lithuania)
|March 27, 2025
概括
偏膜性综合征 (PNS) 在胆囊癌 (GBC) 中很罕见,通常在晚期出现. 虽然管理PNS可以改善生活质量,但它对早期GBC诊断提供了最小的好处.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床医学 临床医学
背景情况:
- 胆囊癌 (GBC) 是一种具有不良生存率的侵袭性恶性瘤,通常是由于晚期诊断.
- 非特异性临床表现的GBC阻碍了早期检测.
- 麻性综合征 (PNS),与癌症相关的症状,可能表明早期恶性瘤.
研究的目的:
- 系统地审查和整理关于PNS和GBC之间的关联的案例研究.
- 了解GBC患者中PNS的表现,管理和临床结果.
主要方法:
- 在主要数据库 (PubMed,Embase,CINAHL,Web of Science,Cochrane) 进行了全面的文献搜索.
- 通过数据库搜索确定了49篇文章,通过引用跟踪发现了2篇额外的文章.
- 提取的数据包括患者人口统计学,PNS类型,诊断时间,提出投诉,调查和治疗有效性.
主要成果:
- 在GBC中呈现的PNS具有血液学,皮肤学,神经学和代谢的表现.
- 常见的PNS包括白细胞症,炎症性肌肉炎,尼格里卡斯,高血症和低血症.
- 大多数PNS在GBC的晚期阶段被诊断出来.
结论:
- 在GBC中PNS管理可以改善患者的生活质量,但在早期诊断中其作用有限.
- 即使在PNS管理下,GBC的瘤治疗结果仍然很差.
- 识别和治疗PNS对于整体的GBC患者护理至关重要.
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