在接受精密益生菌干预的不孕妇女中提炼不利的阴道微生物群体:一项探索性单臂,前性,开放标签,干预性研究
Giovanna Cocomazzi1, Viviana Contu2, Silvia De Stefani3
1Division of Gastroenterology, Fondazione IRCCS-Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, FG, Italy.
Microorganisms
|March 27, 2025
概括
口服益生菌含有特定的乳酸菌和益生菌可以调节阴道微生物群. 这种干预可以通过减少有害细菌和增加有益的乳酸菌来改善生殖健康,这可能有助于辅助生殖技术的成功.
科学领域:
- 微生物学 微生物学
- 生殖科学 生殖科学
- 胃肠病学 胃肠病学
背景情况:
- 阴道微生物组被分为五种社区状态类型 (CST).
- CST-III和CST-IV与阴道失生症有关,增加感染风险和辅助生殖技术 (ART) 失败.
- 健康的阴道微生物组对于成功的繁殖至关重要.
研究的目的:
- 调查口服益生菌补充剂对阴道微生物群组成的影响.
- 评估一种含有阴道特异性乳酸菌和益生菌的益生菌配方在调节阴道微生物组中的有效性.
主要方法:
- 招募了32名先前有IVF周期失败的妇女接受ART.
- 在口服益生菌给药前后分析阴道微生物组合.
- 使用16S核糖体RNA (rRNA) 测序技术进行微生物群分析.
主要成果:
- 口服益生菌补充剂显著调节了阴道微生物群.
- 观察到物种多样性的减少.
- 青乳酸菌和双菌的主导地位,同时减少阿托波比,加德内拉和普雷沃特拉.
结论:
- 口服特定益生菌可以减少阴道微生物群中的致病细菌.
- 这种干预促进了乳酸菌的增加,与健康的阴道生态系统有关.
- 妇科医生可能会考虑对接受试管婴儿的CST-III/IV患者进行精密益生菌治疗,以潜在地改善妊娠成功.
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