细菌性角质炎的流行病学和抗菌素耐药性趋势:一项基于医院的10年研究 (2014-2024年)
Qingquan Shi1, Deshuo Mao1, Zijun Zhang1
1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
Microorganisms
|March 27, 2025
概括
细菌性角膜炎 (BK) 显示病原体的转移和诺基诺抗性的增加,特别是在COVID-19大流行期间. 持续的监测和抗菌药物管理对于有效治疗这种严重的眼部感染至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 细菌性角膜炎 (BK) 是一种严重的眼部感染,可能导致视力丧失.
- 抗微生物药物耐药性 (AMR) 在治疗BK方面构成了重大且日益增长的挑战.
- COVID-19大流行可能影响了BK的病原体分布和抗菌素敏感性模式.
研究的目的:
- 分析导致BK的细菌病原体的趋势及其在十年内对抗菌素的敏感性.
- 为了比较这些趋势在COVID-19前,COVID-19期间和COVID-19后的时期.
- 为了识别病原体流行率的变化和诺基诺耐药性的出现.
主要方法:
- 从角膜感染中分离的1071种细菌的回顾性分析 (2014-2024年).
- 隔离物分类为COVID-19前,COVID-19期间和COVID-19后的阶段.
- 评估病原体分布和抗菌素敏感性,重点关注诺基诺.
主要成果:
- 显著减少了格拉姆阳性菌 (例如,斯塔菲洛科克斯表皮病菌) 和增加了格拉姆阳性细菌 (例如,Corynebacterium spp. ) 的情况.
- 在COVID-19期间,对gatifloxacin,moxifloxacin和ciprofloxacin的敏感性明显下降.
- 斯塔菲洛科克,链球菌和Corynebacterium spp.中gatifloxacin耐药性的大幅增加,在COVID-19后持续存在.
结论:
- 这项研究强调了对BK负责的细菌病原体的显著转变.
- 在关键细菌群体中观察到诺基诺耐药性的快速增加,特别是在COVID-19大流行期间.
- 迫切需要加强抗微生物药物监测和管理,以打击抗药性增加并改善BK治疗结果.
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