患有COVID-19肺炎住院患者的心血管血液动力学受损
Barbara Domino1, Agnieszka Włochacz1, Małgorzata Maciorowska1
1Department of Cardiology and Internal Diseases, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland.
严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染会损害心脏功能,如COVID-19患者阻抗心脏图 (ICG) 所示. ICG可以非侵入性地检测出这种心血管功能障碍,即使在低风险个体中也是如此.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 医疗技术 医疗技术 医学技术
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染与心脏功能障碍有关,特别是在严重的COVID-19病例中.
- 阻抗心脏图 (ICG) 提供了一种非侵入性方法来评估心脏功能和检测血液动力学变化.
- 在住院COVID-19患者中,ICG可能对早期识别心脏问题有价值.
研究的目的:
- 将COVID-19肺炎住院患者的血液动力学概况与对照组进行比较.
- 评估SARS-CoV-2感染对心脏功能的影响,使用阻抗心脏图.
主要方法:
- 一项前性观察性研究,涉及30名住院的COVID-19肺炎患者 (COVID组) 和一个倾向性得分匹配的回顾性对照组 (CG).
- 阻抗心脏图 (ICG) 用于测量血液动力学参数,包括心率 (HR),中风体积指数 (SI),心脏指数 (CI) 和全身血管阻力指数 (SVRI).
- 倾向性得分匹配确保了基于年龄,血压 (BP) 和体重指数 (BMI) 的组之间的可比性.
主要成果:
- COVID-19患者的HR和SVRI显著增加,SI,速度指数 (VI),加速指数 (ACI) 和Heather指数 (HI) 较低.
- 很大一部分COVID-19患者 (37%) 呈现低SI (<35mL/m2),而对照组只有3% (p < 0.0001).
- 在左心室喷射分数 (LVEF) 中发现了统计学上显著的差异,尽管值保持在正常范围内.
结论:
- SARS-CoV-2 感染对心血管系统产生不利影响,导致心脏功能受损,即使在被认为低风险的患者中也是如此.
- 阻抗心脏图 (ICG) 证明是一种简单的,非侵入性的工具,用于识别COVID-19后肺炎的心脏功能障碍.
- 使用ICG早期检测心血管损害可以帮助管理从COVID-19中康复的患者.
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