作为冠状动脉微血管功能障碍的生物标志物,单中心分析可溶性TREM2:一个横截面研究
Yingying Xie1,2, Zhaoxue Sheng1, Haoming He1,2
1Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing 100029, China.
Journal of clinical medicine
|March 27, 2025
概括
在骨髓细胞2 (sTREM2) 上表达的可溶性触发受体水平升高与冠状动脉微循环功能障碍 (CMD) 有关. 较高的sTREM2表明风险增加,有助于诊断CMD,表明其作为生物标志物的潜力.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 在骨髓细胞2 (sTREM2) 上表达的溶性触发受体与心血管疾病有关.
- sTREM2在冠状动脉微循环功能障碍 (CMD) 中的特定作用尚不清楚.
研究的目的:
- 调查sTREM2水平与CMD之间的关联.
- 评估sTREM2作为潜在的CMD诊断生物标志物.
主要方法:
- 76名受试者 (55人患有CMD,21人没有CMD) 的横截面观察研究.
- 通过ELISA测量的sTREM2水平;CMD定义为CFR<2.5或IMR≥25.
- 进行了相关性,回归和ROC分析,以评估sTREM2的关联性和CMD的诊断准确性.
主要成果:
- 与对照组相比,CMD患者的sTREM2水平显著更高.
- sTREM2与IMR正相关,与CFR,MRR和RRR相反.
- sTREM2被确定为CMD的独立风险因素 (OR = 1.003,p = 0.008) 具有良好的诊断性能 (AUC = 0.7677).
结论:
- 升高的sTREM2水平与冠状动脉微循环功能障碍有关.
- sTREM2显示出作为诊断CMD的有价值生物标志物的潜力.
关键词:
对于CFR来说,这是一个很好的方法.在CMD中,CMD是指CMD.在IMR中,IMR是IMR.MRRR MRRR MRRR MRRR MRRR MRRR MRRR MRRR MRRR MRRR MRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRR冠状动脉微循环功能障碍 冠状动脉微循环功能障碍sTREM2 的时间.相关概念视频
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