绝经后妇女的牙损伤状况:系统审查和元分析
Victoria Areal-Quecuty1, Juan J Segura-Egea1, Aurea Simón-Soro1
1Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain.
Journal of clinical medicine
|March 27, 2025
概括
绝经后的女性表现出明显更高的腐烂,缺失和填充牙 (DMFT) 指数,表明牙损伤增加. 这很可能是由于与更年期相关的雌激素下降影响了唾液功能,增加了脏病的风险.
科学领域:
- 口腔健康研究研究 口腔健康研究
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 牙损是一种普遍存在的全球口腔感染,其特点是牙硬组织中的矿物质损失.
- 唾液功能依赖于雌激素;更年期可能导致异构,可能增加虫病的发生率.
- 腐烂,缺失和填充牙指数 (DMFT) 是评估牙损状况的标准指标.
研究的目的:
- 系统地审查和分析更年期对成年妇女牙损伤状况的影响.
- 回答PICO问题:使用DMFT指数,更年期 (I) 与没有更年期 (C) 相比,是否会影响成年女性 (P) 的牙损伤 (O)?
主要方法:
- 遵守PRISMA系统审查和元分析指南.
- 在PubMed/MEDLINE,Scopus和EMBASE数据库中进行的搜索.
- 使用Revman软件 (v. 5.4) 进行的元分析与随机效应模型;使用纽卡斯尔-太华尺度评估偏差风险;使用希金斯I2测试评估异质性;用GRADE方法确定证据的确定性.
主要成果:
- 七项研究包括4396名绝经后妇女和5131名对照.
- 分析显示,绝经后妇女的DMFT指数显著更高 (MD = 3.13;95% CI = 2.12-4.15;p < 0.00001).
- 与对照组相比,绝经后的女性平均有3个更多的腐烂,缺失或填充的牙.
结论:
- 更年期与更糟糕的牙损伤状况有显著的关联.
- 更年期期间雌激素水平下降可能会损害唾液功能,导致脏病的增加.
- 建议进一步研究以阐明机制,并探索预防策略,如激素替代疗法.
相关概念视频
01:15Teeth
275
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
275
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:02What is the Skeletal System?
52.0K
Overview
52.0K
01:28Menopause
110
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
110
01:31Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
01:25Role of Vitamins in Maintaining Bone Health
3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K