口腔微生物组合对代谢功能障碍相关的脂肪性肝病在一般人群中的影响
Satoshi Sato1, Chikara Iino1, Keisuke Furusawa1
1Department of Gastroenterology, Hematology, and Clinical Immunology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
Journal of clinical medicine
|March 27, 2025
概括
口腔微生物群模式与代谢功能障碍相关的脂肪性肝病 (MASLD) 有关. 维龙氏菌口腔微生物群是MASLD的风险因素,而尼塞利亚菌则显示出保护性相关性.
科学领域:
- 微生物组研究的研究.
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 口腔微生物群在MASLD病原体中的作用尚未完全理解.
- 调查口腔微生物群组成可能会揭示对MASLD风险因素的新见解.
研究的目的:
- 在一般人群中检查不同口腔微生物群模式与MASLD之间的关联.
- 确定与MASLD和心脏代谢风险因素相关的特定口腔细菌群.
主要方法:
- 主要成分和集群分析被用来将712名参与者分为四个口腔微生物群组:尼塞里亚菌,链球菌,Fusobacterium和Veillonella.
- 尼塞里亚小组作为多变量分析的参考.
- 评估了口腔细菌物种和MASLD/心脏代谢参数之间的相关性.
主要成果:
- 在Veillonella口腔微生物群被确定为MASLD的独立风险因素.
- 尼塞里亚与MASLD指标 (如控制衰减参数,BMI和肝酶) 有负相关性.
- 维龙内拉与众多MASLD指标呈现正相关性,与HDL胆固醇呈现负相关性.
结论:
- 特定的口腔微生物群模式,特别是Veillonella,与MASLD有显著的关联.
- 口腔卫生和牙周炎预防可能在减轻MASLD风险方面发挥作用.
- 对口腔肝轴的进一步研究可以为MASLD的预防策略提供信息.
相关概念视频
01:24Overview of Lipid Metabolism
885
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
885
01:23Anatomy of the Intestines
71.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.1K