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在静态冰存储期间猪和人类肺部的温度动态:冰不是4°C
Ismail Cenik1,2, Jan Van Slambrouck1,2, Annalisa Barbarossa1,2
1Department of Thoracic Surgery, University Hospitals Leuven, 3000 Leuven, Belgium.
Journal of clinical medicine
|March 27, 2025
概括
静态冰储存 (SIS) 用于肺部保存,温度快速降至4°C以下,可能导致伤. 在SIS之后,捐赠者的肺部温度有很大的变化,并不能始终保持在假定的4°C.
科学领域:
- 器官移植 器官移植 器官移植
- 低温生物学 低温生物学
- 进行手术的保存.
背景情况:
- 静态冰储存 (SIS) 是肺部保存的标准方法.
- 假设它可以保持4°C的温度.
- 这种假设缺乏直接温度测量确认.
研究的目的:
- 在静态冰存储期间测量肺部和保存溶液温度.
- 评估使用SIS在猪模型和临床肺部保存中实现的实际温度.
- 评估由于低于最佳温度而导致伤的风险.
主要方法:
- 使用SIS,猪肺被保存了3-8小时.
- 监测了肺组织,保存溶液和盐水的温度.
- 在SIS期间和储存后测量了临床肺部保存温度.
- 在SIS之前和之后评估了表面和核心肺部温度.
主要成果:
- 猪肺组织,保存溶液和盐水的温度在几个小时内下降到4°C以下,接近0°C.
- 临床保存溶液在几分钟内低于4°C,在78-267分钟内达到0°C.
- 在SIS后的肺部温度表现出显著的变化,表面温度中位数为1.25°C,核心温度为1.45°C.
结论:
- 静态冰的储存导致温度迅速显著下降,低于假设的4°C.
- 在SIS之后,捐赠者的肺部温度是可变的,并且可能低于安全限值.
- 这种变化带来了冷伤害和冷损伤的风险,保存的肺部.
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