酸作为交叉连接剂在肠道微囊的开发中用于Posaconazole
Marta Szekalska1, Giedrė Kasparavičienė2, Jurga Bernatonienė2
1Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, Poland.
Pharmaceutics
|March 27, 2025
概括
酸交叉链接的阿尔金酸盐和点微囊改进了波萨可纳.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 菌类学 菌类学是指菌类学.
背景情况:
- 可纳是一种三醇抗真菌剂,表现出由胃状况影响的可变生物利用性.
- 肠道药物制剂提供了一种解决方案,使得可萨可纳的吸收一致,而不依赖于食物摄入.
- 多个单位的剂量形式,如微囊,增强胃肠道的分布和可预测的胃排空.
研究的目的:
- 为了评估酸的交叉链接阿尔金酸盐和pectin混合物成微囊.
- 评估交叉链接和pectin对药物,粘膜,物理化学和抗真菌性质的影响.
- 开发一个稳定有效的波萨可纳输送系统.
主要方法:
- 酸与酸交叉连接的酸盐-pectin微的配方.
- 从微囊中评估波萨可纳释放动力学.
- 对Candida菌株的抗真菌活性和粘粘性质的评估.
主要成果:
- 酸的交叉链接导致波萨可纳的释放延迟.
- 与Zn2+离子交联显著增强了对Candida菌株的抗真菌活性.
- 素的结合改善了肠道状况的胀,并增强了对肠道粘膜的粘合性.
结论:
- 酸与酸交叉连接的酸-pectin微囊代表了一种有前途的方法,可以改善波萨可纳的输送.
- 开发的配方增强了抗真菌功效和粘粘性质,可能改善治疗结果.
- 该战略解决了波萨可纳的生物可用性挑战,提供了更可靠的治疗选择.
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