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Stefano Sangiorgi¹, Beatrice Albertini¹, Serena Bertoni¹

¹Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, I-40127 Bologna, Italy.

|March 27, 2025

概括

离子液体 (ILs) 和深溶解剂 (DESs) 越来越多地用于口服难溶性药物的药物输送. 本综述涵盖了它们的特性,制造,毒性和应用,强调了未来研究的领域.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
绿色化学绿色化学

背景情况:

离子液体 (ILs) 和深溶剂 (DESs) 已经成为多功能材料,在催化,提取和生物技术中具有应用.
它们在制药研究中的使用,特别是用于药物输送,在过去十年中大幅扩大.
本综述重点介绍的是针对口服药物的IL和DES,这些药物具有较差的生物制药特性.

研究的目的:

为口服药物输送提供ILs和DESs的全面审查.
为了分类和描述各种IL和DES,包括自然 (Bio-IL,NaDES) 和治疗 (API-IL,TheDES) 的子类,以及表面活性离子液体 (SAIL).
评估与这些溶剂相关的制造方法,可持续性,可扩展性和毒性问题.

主要方法:

文献审查和对口服药物输送中的IL和DES现有研究的分析.
根据其特性和应用,对不同类型的IL和DES进行分类和分类.
制造工艺,环境影响和毒理学概况的评估.
分析它们在纯粹的形式或在口服的各种剂量形式中使用的情况.

主要成果:

IL和DES提供了有前途的解决方案,以提高口服药物的药物输送,而生物制药性质较差.
包括Bio-ILs,NaDESs,API-ILs,TheDESs和SAILs在内的各种子类表现出适用于药物输送的独特特征.
在不同的IL和DES中,制造方法和毒性概况各不相同,需要对特定应用进行仔细考虑.

结论:

ILs和DESs代表了口服药物递送系统的重大进步.
进一步的研究至关重要,以了解它们与生物系统的相互作用,长期稳定性,并开发优化的药物输送配方.
对可持续制造和安全概况的持续调查将促进它们更广泛的临床应用.

关键词:

它们是API-ILs.这里是 DESs.它们是 ILs ILs ILs.纳德斯 (NaDES) 的时间增强生物可用性增强生物可用性药物溶解化药物溶解化绿色化学是一种绿色化学.制造方法制造方法口服药物输送是通过口服药物进行的.毒性的毒性毒性的毒性

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