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Updated: May 20, 2025

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使用生理学基础的药物动力学建模,评估elexacaftor-tezacaftor-ivacaftor和他类药物之间的复杂药物相互作用

Eunjin Hong1,2, Peter S Chung3,4, Adupa P Rao3,4

  • 1College of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si 13488, Gyeonggi-do, Republic of Korea.

Pharmaceutics
|March 27, 2025
PubMed
概括

囊性纤维化转膜导电调节器 (CFTR) 和他类药物之间的药物相互作用可能会增加他类药物的水平. 阿托瓦斯塔丁显示出最高的风险,而罗斯瓦斯塔丁的相互作用较弱,需要对某些他类药物进行剂量调整.

关键词:
史塔丁类药物是一种囊性纤维化 (CF)囊性纤维化转膜导电调节器 (CFTR) 调节器细胞染色体P450异酶 (CYP) 的使用.药物 药物相互作用有机阴离子载体多 (OATPs) 是一种有机阴离子载体多.基于生理学的药理动力学 (PBPK)

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