基于纳米乳液的药物输送在不同的输送路径上的进展.
Maria D Chatzidaki1,2, Evgenia Mitsou1,3
1Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece.
Pharmaceutics
|March 27, 2025
概括
纳米乳液 (NNEs) 是多功能药物递送系统,增强生物可用性和保护化合物. 本综述涵盖了近期在各种管理途径中NE应用的进展,包括新兴的超神学用途.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 纳米乳液 (NEs) 对药物输送具有显著的优势,包括改善生物可用性,化合物保护和低毒性.
- 它们的多面性质导致了治疗应用的广泛研究和开发.
研究的目的:
- 审查基于纳米乳液的药物输送系统最近 (过去五年) 的进展.
- 探索跨多种管理路径的NE应用: (通过) 皮肤,口腔,眼睛,鼻子和关节内.
- 突出新兴应用,如疫苗接种和治疗术,并讨论临床试验进展.
主要方法:
- 文献综述专注于过去五年的出版物.
- 对NE组件选择和表面功能化策略的分析.
- 检查基于NE的系统,包括凝及其治疗潜力.
主要成果:
- 在优化NE配方以适应特定的注射途径方面取得了显著进展.
- 成功地将透增强剂和向部分纳入,以提高有效性.
- 在疫苗和治疗术等新型应用中出现NE,临床试验的出现越来越多.
结论:
- 纳米乳液代表了一个快速发展的平台,用于先进的药物输送.
- 对合理设计,功能化和新型应用的持续研究将推动未来的治疗突破.
- 解决关键挑战对于广泛采用基于NE的临床疗法至关重要.
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