相关实验视频
Updated: May 20, 2025

07:21
Twin-Screw Extrusion Process to Produce Renewable Fiberboards
Published on: January 27, 2021
6.3K
在双螺杆挤出工艺中模拟剪切薄流
Vincent Kimmel1,2, Lorena Gräfe1, Luca Grieser1
1Laboratory of Solids Process Engineering, Department of Biochemical and Chemical Engineering, Technical University Dortmund, Emil-Figge-Str. 68, 44227 Dortmund, Germany.
Pharmaceutics
|March 27, 2025
概括
这项研究模拟了用于制药配方的热挤出中的螺丝元件行为. 它量化了牛顿和剪切稀释流体的参数,帮助优化螺丝配置.
科学领域:
- 制药技术 制药技术 制药技术
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
背景情况:
- 热挤出 (HME) 是一种关键的制药配方技术.
- 为HME优化螺丝配置具有挑战性,特别是对于复杂的流体行为.
- 现有的模型往往缺乏用于剪切稀释配方的详细螺丝参数数据.
研究的目的:
- 实验性地描述各种螺丝元件在热挤出中的行为.
- 开发一个模型来预测用牛顿式和剪切稀释流体的螺丝元件性能.
- 为增强配方设计提供特定的几何螺丝参数.
主要方法:
- 使用定制的测试装置测量压力和功率.
- 使用牛顿式油和剪切稀释的测试输送和制元件.
- 开发了一个六参数模型 (A1-A3,B1-B3) 和一个附加两个参数的评估框架.
主要成果:
- 牛顿流体的实验数据与现有文献和Pawlowski方法保持一致.
- 量化了螺丝转速对剪切稀释液体压力和功率的影响.
- 确定螺丝参数的置信区间,有效地区分元素类型.
结论:
- 成功建模了几何螺丝参数,适用于牛顿式和剪切稀释流量条件.
- 描述了三个输送和三个制元件,为HME流程优化提供了宝贵的数据.
- 开发的模型和参数为改善制药HME的螺丝配置提供了一个框架.
相关概念视频
Thin-Walled Hollow Shafts
159
In analyzing a thin-walled hollow shaft subjected to torsional loading, a segment with width dx is isolated for examination. Despite its equilibrium state, this segment faces torsional shearing forces at its ends. These forces are quantitatively described by the product of the longitudinal shearing stress on the segment's minor surface and the area of this surface, leading to the concept of shear flow. This shear flow is consistent throughout the structure, indicating a uniform distribution...
159
Typical Model Studies
200
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
200
Couette Flow
163
Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...
163
Types of Fluids
139
Fluids can be classified into Newtonian and non-Newtonian fluids based on their response to shear stress. Newtonian fluids have a linear relationship between shear stress and the shear strain rate, following Newton's law of viscosity. Their viscosity remains constant regardless of the shear rate, making their behavior predictable and easier to analyze. Common examples include water, air, oil, and gasoline.
In contrast, non-Newtonian fluids do not follow Newton's law of viscosity, and...
In contrast, non-Newtonian fluids do not follow Newton's law of viscosity, and...
139
Design Example: Creating a Hydraulic Model of a Dam Spillway
110
Scaled hydraulic models of dam spillways provide a practical way to replicate and study the intricate flow dynamics of these structures. Often built to a 1:15 ratio, these models allow for observing critical water behavior, such as velocity distribution, flow patterns, and energy dissipation.
110
Newtonian Fluid: Problem Solving
165
Newtonian fluids exhibit a constant viscosity, meaning their shear stress and shear strain rate are directly proportional. This property ensures a predictable and stable response to applied forces, maintaining a linear relationship between force and flow. Examples include water, air, and light oils, consistently demonstrating this proportional behavior regardless of external conditions.
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
165

