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Updated: May 20, 2025

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开发和评估Fluconazole联合晶体,以提高可溶性和机械性能

Ritu Rathi1, Inderbir Singh1, Tanikan Sangnim2

  • 1Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India.

Pharmaceutics
|March 27, 2025
PubMed
概括

与酸一起开发可纳联合晶体显著提高了溶解性,稳定性和流动性. 这种可纳联合晶体提供了改进的制造和药物输送潜力.

关键词:
这是一种抗真菌药物.共同晶体的共同晶体压缩 压缩是一种压缩.压缩压缩压缩压缩压缩溶解度 溶解度 溶解度 溶解度可以表达的表格性.

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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