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Updated: May 20, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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利用奥梅普拉PBPK/PD建模来告知药物相互作用,并为儿科标签提供具体建议

Amira Soliman1,2, Leyanis Rodriguez-Vera1,3, Ana Alarcia-Lacalle4,5

  • 1Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.

Pharmaceutics
|March 27, 2025
PubMed
概括

一个新的基于生理学的药理动力学 (PBPK) 模型准确地预测了儿童的奥梅普拉代谢和疗效. 这种PBPK-PD模型有助于优化儿科剂量和药物开发,解决与年龄相关的变化.

关键词:
这是一个PBPK-PD.年龄生理变化 - - 生理变化.发展变化 发展变化欧梅普拉 (omeprazole) 是一种药物.儿科 儿科 儿科 儿科

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