基于微流体系统制备的黄素-脂复合纳米悬浮体的物理化学表征和口服生物利用性
Bo Zhang1, Wenjing Guo1, Zhenyu Chen1
1Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Pharmaceutics
|March 27, 2025
概括
黄素-脂复合纳米颗粒 (CPC-NP) 的微流体制剂显著提高了黄素的生物可用性. 这些新型纳米粒子与自由黄素及其复杂形式相比,表现出优越的药物动力学特征.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 黄素在抗炎,抗菌,抗氧化和神经保护方面表现出治疗潜力.
- 较差的水溶性,稳定性和快速代谢限制了黄素的生物可用性和临床应用.
- 微流体技术提供了一种新的方法来提高黄素的生物可用性.
研究的目的:
- 通过微流体制备技术提高黄素的生物可用性.
- 开发具有增强性质的黄素-脂复合纳米粒子 (CPC-NP).
- 评估大鼠中CPC-NP的药物动力学概况.
主要方法:
- 使用自制的微流体系统,使用聚乙烯基罗利 K30 和二甲基硫酸盐作为稳定剂制备CPC-NP.
- 使用XRD,DSC,动态光散射和TEM进行了CPC-NP的特征.
- 通过酶消化和HPLC在老鼠中评估了黄素,CPC,CUR-NP和CPC-NP的药理动力学.
主要成果:
- 优化CPC-NP的颗粒大小为71.19 ± 1.37nm,PDI为0.226 ± 0.047,和泽塔电位为-38.23 ± 0.89mV.
- TEM证实了球形结构,XRD/DSC表明成功集成和无形转换.
- 与其他配方相比,CPC-NP显示Cmax (2163.87 ± 777.36 ng/mL) 和AUC0-t (9494.28 ± 1863.64 ng/mL/h) 显著更高.
结论:
- 微流体制剂产生的CPC-NP与传统方法相比具有更高的质量控制.
- 在CPC-NP中,比自由黄素,CPC和CUR-NP显著提高了生物可用性.
- 需要进一步的药学动力学研究来验证抗炎,抗氧化和神经保护作用.
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