在挪威对抗传染性脑炎病毒的抗体进行了回顾性血清监测研究
Alaka Lamsal1,2, Katrine Mørk Paulsen1, Maria Juul Diekmann1
1Department of Virology, Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, 0456 Oslo, Norway.
Viruses
|March 27, 2025
概括
传染性脑炎病毒 (TBEV) 感染在挪威的特有和非特有地区都有类似的低患病率. 这表明TBEV的潜在诊断不足,强调需要准确的诊断方法.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 感染性脑炎病毒 (TBEV) 引起类似流感的症状,并可能导致中枢神经系统 (CNS) 感染.
- 在挪威南部,TBEV是特有的,从特有地区报告的病例,但在虫中它的流行在沿海地区很普遍.
- 了解挪威各地的TBEV感染状况对于公共卫生至关重要,尤其是在区分特有地区和非特有地区时.
研究的目的:
- 确定TBEV在挪威的血清流行,包括特有和非特有地区.
- 在非流行地区调查潜在的亚临床或无症状TBEV感染.
- 评估诊断方法的准确性,并确定TBEV测试中的交叉反应性问题.
主要方法:
- 1940年挪威19个县的残留血清样本的分析.
- 使用ELISA进行初始查,随后进行TBEV的确认性病毒中和试验.
- 包括来自中枢神经系统感染患者的137个样本在非流行地区进行进一步分析.
主要成果:
- 在挪威观察到类似的TBEV血清流行 (1.7%在特有地区,1.6%在非特有地区).
- 只有43%的ELISA阳性样本被病毒中和证实,这表明潜在的错误阳性.
- 在有中枢神经系统症状的患者中没有证实TBEV感染;整个队列的整体血清流行率为0.7%.
结论:
- 这些发现表明,在挪威非流行地区,潜在的低诊断和无症状的TBEV感染可能存在.
- 该研究强调了使用确认性测试 (如病毒中和) 来准确诊断TBEV感染的重要性.
- 与其他黄状病毒的交叉活性需要仔细解释诊断结果,特别是在混合病毒循环的地区.
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