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系统性炎症反应与乙型肝炎疫苗不响应的关联

Oguz Karabay¹, Kaan Furkan Hamarat², Gamze Guney Eskiler³

¹Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Türkiye.

|March 27, 2025

概括

乙肝疫苗不响应者表现出更高的全身炎症指标,包括白细胞和中性粒细胞的升高. 中性粒细胞与淋巴细胞的比率 (NLR) 可能有助于识别不对乙型肝炎疫苗接种有反应的个人.

科学领域:

免疫学免疫学免疫学
血液学血液学血液学
肝病学肝病学是一种肝病学.

背景情况:

乙型肝炎病毒 (HBV) 感染是一个重大的全球健康问题.
疫苗接种失败发生在5-10%的风险人群中,需要对预测因素进行研究.
血液学指数与HBV相关的肝病和患者的结局有关.

研究的目的:

研究炎症标志物与乙型肝炎疫苗反应之间的关联.
探索血液学指数在预测疫苗响应性方面的作用.

主要方法:

对90名志愿者的回顾性分析 (46名受访者,44名非受访者).
收集的人口统计和血液图数据.
计算的全身炎症指数 (SII),血小板与淋巴细胞的比率 (PLR) 和中性粒细胞与淋巴细胞的比率 (NLR).

主要成果:

与响应者相比,不响应者表现出明显更高的白细胞,淋巴细胞,中性粒细胞和血小板的中位数.
系统性炎症指数 (SII) 和中性粒细胞与淋巴细胞的比率 (NLR) 在未反应者中显著增加 (p <0.05).

结论:

不对乙型肝炎疫苗接种反应的患者表现出系统性炎症标志物增加.
中性粒细胞与淋巴细胞的比率 (NLR) 显示出在区分乙型肝炎疫苗反应方面有潜力.
需要进行更大的队列研究来验证系统性炎症作为疫苗反应的预测因素.

关键词:

乙型肝炎病毒的感染.免疫反应的免疫反应.炎症参数炎症参数系统性炎症系统性炎症接种疫苗的反应反应.

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