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Updated: May 20, 2025

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肝炎E病毒的遗传多样性和分子进化 在蝙蝠的基因 chirohepevirus 中
Bo Wang1, Peter Cronin1, Marcus G Mah1
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Viruses
|March 27, 2025
概括
蝙蝠衍生型肝炎E病毒 (HEV) 的多样性正在扩大. 研究人员在蝙蝠中发现了新的chirohepevirus菌株,这表明了潜在的动物感染风险和病毒与宿主共同物种化.
科学领域:
- 病毒学 病毒学
- 基因组学就是基因组学.
- 进化生物学 进化生物学
背景情况:
- 肝炎E病毒 (HEV) 是一种具有多样性动物储库的显著动物性病原体.
- HEV分类包括五个属,蝙蝠衍生的病毒组成了基洛赫佩病毒属.
- 最近的测序揭示了蝙蝠中的许多HEV相关病毒,促使对它们的动物感染潜力进行调查.
研究的目的:
- 分析蝙蝠中的基因多样性和chirohepeviruses的进化模式.
- 识别新的HEV菌株并评估它们与已知的HEV物种的关系.
- 了解蝙蝠相关的HEV的潜在动物传染性影响.
主要方法:
- 分析了来自9个国家的22种蝙蝠的64个chirohepevirus序列.
- 12个完整或几乎完整的病毒基因组的全基因组测序.
- 使用最大概率方法进行的族遗传学分析.
主要成果:
- 在宿主属/物种内的奇洛赫佩病毒菌株中确定了高序列分歧 (>25%).
- 在奇罗赫佩病毒中发现了至少七个不同的子类,可能代表新的物种.
- 观察到基洛赫佩病毒菌株与它们的蝙蝠宿主之间存在强烈的相关性,这表明了共同物种化.
结论:
- 这项研究显著扩大了已知的Hepeviridae家族的多样性,特别是蝙蝠相关的HEV.
- 研究结果表明,在奇罗赫佩病毒中存在病毒与宿主共同分类的模式.
- 持续监测chirohepevirus对于评估动物传播风险和公共卫生影响至关重要.
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