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血清预素升高识别了疹简单病毒-1在COVID-19患者中的重新激活

Patricia Mester¹, Dennis Keller¹, Claudia Kunst¹

¹Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, Immunology, and Infectious Diseases, University Hospital Regensburg, 93053 Regensburg, Germany.

|March 27, 2025

概括

在严重的COVID-19中,升高的普雷塞普辛水平可能与简单疹病毒-1 (HSV-1) 活性化有关,而不是细菌或真菌感染. 这一发现影响了对COVID-19生物标志物和疾病进展的理解.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

素,一种可溶性CD14片段,是COVID-19严重程度的潜在生物标志物.
严重的COVID-19患者经常经历二次细菌,真菌或病毒感染.
这些感染可能会使疾病的进展复杂化,并影响生物标志物的解释.

研究的目的:

为了研究同时感染对COVID-19患者血清前素水平的影响.
为了区分细菌/真菌超级感染与HSV-1再激活对普雷塞普辛的影响.
澄清前素作为严重COVID-19中的生物标志物的作用.

主要方法:

使用ELISA测量了63名中度COVID-19患者,60名严重COVID-19患者和49名对照者的血清前素水平.
分析了与前素的相关性和超级感染或HSV-1再激活的存在.
在患者组和对照组之间进行了统计比较.

主要成果:

严重的COVID-19患者比中度病例有更高的前素 (p=0.002);没有幸存者有更高的水平 (p=0.027).
在这两组中,普雷塞普辛与前citonin都有正相关性.
与细菌/真菌感染不同的是,HSV-1复激活显著增加了前素 (p=0.002),而不是细菌/真菌感染.
排除HSV-1病例消除了中度和严重的COVID-19前素水平之间的差异.

结论:

在严重的COVID-19中,血清前素的升高主要与简单疹病毒-1 (HSV-1) 的重新激活有关.
细菌或真菌超级感染不会显著影响前素水平.
作为COVID-19的严重性生物标志物的普雷塞普辛的实用性可能会被HSV-1重新激活所混.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.这是一种细菌超级感染.疹简单病毒病毒.在前列表中,我们可以看到前列表.

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