免疫抑制患者的HBV重新激活:查,预防和管理,包括固体器官移植接受者
Philip Vutien1, Mindie H Nguyen2,3
1Division of Gastroenterology and Hepatology, University of Washington Medical Center, 1959 NE Pacific Street, Box 356175, Seattle, WA 98195, USA.
Viruses
|March 27, 2025
概括
乙型肝炎病毒 (HBV) 再激活对免疫抑制患者来说是一个严重的风险. 本综述提供了关键的查和管理策略,以防止高危人群中的HBV重新激活.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 乙型肝炎病毒 (HBV) 感染影响全球超过2.54亿人.
- 慢性HBV感染导致严重的肝病,如肝硬化,肝衰竭和肝细胞癌.
- 乙型肝炎病毒的重新激活构成重大威胁,特别是在免疫受损的个体中.
研究的目的:
- 概述HBV重新激活的查协议.
- 在特定的患者群体中详细介绍HBV重新激活的管理策略.
- 针对非移植和固体器官移植受体的HBV再激活.
主要方法:
- 对当前查指南的文献综述.
- 分析既有和新兴的抗病毒疗法.
- 对管理方法的临床证据的综合.
主要成果:
- 识别需要警监测的高风险患者群体.
- 针对预防性抗病毒疗法的基于证据的建议.
- 在免疫抑制治疗期间和之后管理HBV再激活的策略.
结论:
- 积极的查和及时的管理对于预防HBV重新激活至关重要.
- 针对非移植和固体器官移植受体,需要量身定制的策略.
- 有效的管理可以减轻HBV重新激活的严重后果.
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