微生物治疗的首选报告项目 (PRIM) 跨医学学科的指导方针:国际德尔菲共识
Faming Zhang1, Michael A Kamm2, Xia Wu1
1Department of Microbiota Medicine and Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Journal of gastroenterology and hepatology
|March 27, 2025
概括
为改善研究透明度和评估,制定了微生物治疗报告准则 (PRIM 2024). 这些指南确保了便微生物种移植,菌体治疗,益生菌和共生菌的一致报告.
科学领域:
- 微生物学 微生物学
- 临床研究方法论 临床研究方法论
背景情况:
- 微生物疗法对与失生症相关的疾病有前途,但缺乏标准化的报告,阻碍了结果解释和安全性评估.
- 现有的研究往往省略了关键的报告项目,影响了透明度和可重复性.
研究的目的:
- 制定和验证微生物治疗研究的综合报告准则.
- 提高微生物治疗研究的质量,透明度和可比性.
主要方法:
- 第1阶段:制定了初始的微生物治疗首选报告项目 (PRIM) 检查清单,并评估了其在瘤学研究中的应用 (2011-2023年).
- 第二阶段:通过与国际专家小组 (22名专家) 达成的德尔菲共识,完善和最终确定PRIM指南 (PRIM2024).
主要成果:
- 只有39.3%的审查瘤学研究符合PRIM初始检查清单的所有项目.
- 基于培养的微生物治疗研究比非基于培养的研究得分更高.
- 最终完成的PRIM 2024指南包括10个声明和18个点,涵盖微生物治疗报告的关键方面.
- 专家小组认为,在PRIM积分的80%以下的报告质量不佳.
结论:
- PRIM 2024指南为微生物治疗研究报告提供了一个标准化的框架,包括便微生物种移植,菌体治疗,益生菌和共生菌.
- 一致和透明的报告将有助于更好地评估,比较和实施微生物治疗发现.
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