在间歇性肺病的急性恶化和移植后的存活率期间进行肺移植
Daniel M Guidot1, Jeremy M Weber2, Aparna C Swaminathan1,2
1Duke University Medical Center Department of Internal Medicine, Division of Pulmonary and Critical Care, Durham, North Carolina.
JHLT open
|March 27, 2025
概括
在间歇性肺病 (AE-ILD) 急性恶化期间的肺移植显示出有希望的1年生存率. 精心挑选的AE-ILD患者的结果与其他肺移植接受者相似,但没有长期增加移植功能障碍.
科学领域:
- 肺部病理学 肺部病理学
- 移植手术 移植手术
- 关键护理医学 关键护理医学
背景情况:
- 间歇性肺病 (AE-ILD) 的急性恶化与高死亡率有关,尽管接受了治疗.
- 肺移植是末期间歇性肺病 (ILD) 的一个可行的选择.
- 关于AE-ILD患者肺移植后结果的现有数据是矛盾的.
研究的目的:
- 评估患者经历AE-ILD的肺移植的结果.
- 为了比较AE-ILD患者与其他ILD肺移植接受者的生存率和长期移植功能.
主要方法:
- 对717名首次肺移植接受者进行ILD的回顾性分析 (2005年5月至2019年4月).
- 患者分为AE-ILD,其他住院患者和门诊患者组.
- 使用考克斯比例危险模型分析的一年生存率;对异常性肺纤维化 (IPF) 的子集分析;对慢性肺异常功能障碍 (CLAD) 的评估.
主要成果:
- 一年生存率为AE-ILD的93%,其他住院患者的61%,门诊患者的82%.
- 与其他住院和门诊患者相比,AE-ILD接受者死亡或再移植的风险明显较低.
- 在AE-ILD接受者和其他群体之间没有观察到1年CLAD率的显著差异.
结论:
- 仔细的选择允许在AE-ILD患者中成功进行肺移植.
- 在AE-ILD期间的移植与可接受的1年结果有关.
- 接受AE-ILD肺移植的患者不会面临长期移植功能障碍的风险增加.
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