在静脉封闭性疾病中的操作程序共享途径:基于德尔菲共识的建议
Francesca Bonifazi1, Federico Ravaioli1, Anna Paola Iori2
1Department of Translational and Precision Medicine, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Frontiers in oncology
|March 27, 2025
概括
这项研究强调了在意大利进行干细胞移植后管理静脉封闭性疾病 (VOD) 的显著区域差异. 它建议标准化方案和早期的除纤维化物治疗,以获得更好的患者结果.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 胃肠病学 胃肠病学
背景情况:
- 静脉封闭性疾病 (VOD) 或阴道阻塞综合征 (SOS) 是化学疗法和造血干细胞移植 (HSCT) 后的一种严重并发症.
- 意大利在VOD诊断和管理实践方面存在显著的区域差异.
研究的目的:
- 在意大利临床实践中标准化VOD的诊断和治疗途径.
- 为了解决意大利不同地区的VOD管理的变化.
主要方法:
- 一个为期12个月的Delphi共识项目,涉及一个方法学家,科学委员会和45名专业临床医生.
- 使用了独立的贡献,协调和网络会议讨论.
主要成果:
- 在五个关键领域确定了15个临床主题,包括HSCT前评估,诊断,治疗,EBMT标准整合,成像和除纤维化物管理.
- 建议每周对VOD监测,早期诊断和除纤维化物治疗进行成像,并在各中心采取统一的方法.
结论:
- 在意大利中心的VOD管理中存在显著的变化,需要采用多学科的方法.
- 建立一个国家网络,标准化协议和利用先进的成像技术对于改善HSCT的VOD诊断和治疗结果至关重要.
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