呼吁在心胸移植中开展细胞巨乳病毒管理倡议
Hanna L Kleiboeker1, Jillian L Descourouez2, Emily M Garcia2
1Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois.
细胞巨乳病毒 (CMV) 感染会影响心胸移植的结果. 实施CMV抗病毒管理 (AVS) 计划可以优化预防,治疗和监测,以改善患者和移植者的生存率.
科学领域:
- 移植医学 移植医学 移植医学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 细胞巨乳病毒 (CMV) 感染仍然是心胸移植 (CT) 后的重大挑战,尽管有可用的疗法.
- 冠状病毒对移植和患者的结果产生负面影响,包括动脉样硬化和慢性肺异位移植功能障碍等长期并发症.
研究的目的:
- 审查心脏和肺移植接受者的CMV预防,监测和治疗策略.
- 突出CMV抗病毒管理 (AVS) 计划的机会,以改善CT移植结果.
- 适应AVS概念从腹部移植到CT设置.
主要方法:
- 审查当前的CMV预防,监测和治疗策略在CT移植.
- 将CMV AVS原则应用于CT移植程序.
- 对指导方针实施的器官和患者特定数据的评估.
主要成果:
- CMV AVS为器官特异性护理提供了一个框架,优化预防和治疗.
- 根据当地数据和专家的意见来制定定制的CMV指导方针,可以改善结果.
- 成功实施AVS可以促进特定于CMV的细胞介导免疫力.
结论:
- 在CT移植后,CMV AVS对于改善移植和患者存活率至关重要.
- 将AVS与器官和患者特定数据集成解决了独特的CT移植挑战.
- 多学科的AVS计划可以改善长期的结果,并管理CMV相关的并发症.
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