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Brian Hsi¹, Johanna Van Zyl¹, Komal Alam¹

¹Baylor University Medical Center, Dallas, Texas.

|March 27, 2025

概括

捐赠者衍生的无细胞DNA (dd-cfDNA) 测定,Allosure和Prospera,显示了对心脏移植排斥监测的可比性能. 这两种测试可以互换使用,为移植后患者的监测提供了灵活性.

科学领域:

心脏病学心脏病学
移植免疫学移植免疫学
分子诊断学分子诊断学

背景情况:

来自捐赠者的无细胞DNA (dd-cfDNA) 测试是监测心脏移植受体的新兴工具.
领先的dd-cfDNA测定,Allosure和Prospera之间的比较数据有限.
了解测试性能对于有效的排斥监测至关重要.

研究的目的:

在心脏移植接受者中比较Allosure和Prospera dd-cfDNA测定的性能.
在识别潜在的排斥时评估测试一致性和不一致性.
为了确定测试是否可用于临床监测.

主要方法:

248名连续心脏移植患者样本的回顾性分析.
同时执行Allosure和Prospera的dd-cfDNA测定.
测定结果与活检数据的比较,如果有 (n=26).

主要成果:

这两种测试都正确地确定了与活检结果相关的排斥.
使用制造商推的切断值,观察到一个显著的不一致率 (23/248).
与Prospera相比,Allosure显示出异常分类的比率更高 (p=0.004).
当同样的值适用于两种测试时,没有发现分类的显著差异.

结论:

无论是Allosure还是Prospera的dd-cfDNA测定都显示出对心脏移植排斥监测的可比效用.
这些测试可以被认为是常规监测的互换.
进一步的研究可以完善每个测试的最佳切断值.

关键词:

急性全移植器的拒绝情况急性细胞排斥细胞排斥通过抗体介导的排斥.来自捐赠者的无细胞DNA.心脏移植心脏移植手术

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